WAVE HEALTH SELECTED FOR TWO PRESTIGIOUS POSTER PRESENTATIONS AT ISPOR EUROPE 2024 GLOBAL HEALTH CONFERENCE

Barcelona, Spain and El Segundo, CaliforniaNov 18

ACCEPTED ABSTRACTS INCLUDE:

Spain PRO-WAVE1 study, conducted with eight hospitals, “PRO-WAVE1: Monitoring patient reported outcomes (PROs) in prostate cancer through Wave Health, a novel ePRO health platform” (presents on November 18)

UK feasibility study, conducted with Health Innovation Oxford & Thames Valley, “Enhancing Prostate Cancer Management with Wave Health (Digital Health Platform): A feasibility study” (presents on November 20)


Barcelona, Spain and El Segundo, California – Treatment Technologies & Insights, Inc. (TTI) parent company of the Wave Health digital health platform, today announced that ISPOR, the professional society for health economics and outcomes research, has accepted two study abstracts that positively assessed the Wave Health tool designed to help both patients and care teams. A globally recognized digital health solution, (1) Wave Health activates patient engagement, compliance and personalized supported self-management while streamlining care workflows for treatment teams through automated communication and novel remote monitoring.

The Spain PRO-WAVE1 real world evidence study demonstrated a rare 93% patient compliance (despite a majority of participants being of older age, lower education, and low-tech confidence), alongside a 98% HCP perceived usefulness. Additionally, after completing the study, 78% of patients also responded to an optional feedback survey regarding their experience using Wave Health as a tool for tracking and managing their health during treatment. Those patients conveyed remarkable experiences, including: 90% reporting being satisfied with the app to track their activities and keep their medical team informed; and 95% describing the information provided by Wave Health as “useful” for their treatment journey.

The UK feasibility study was conducted to better understand NHS unmet clinical needs, with a specific focus on the prostate cancer (PC) pathway and ways to improve patient-centered care to impact short and long-term patient management.

The results showcased NHS stakeholders positively reviewing Wave Health to impact cancer management. Notably, the majority agreed the platform had the potential to support clinical decision making, improve patient management, reduce administrative workflow, and achieve costs savings.

TTI CEO Matt Lashey said: “We are honored to have multiple studies recognized at ISPOR and excited to be proving out the opportunity to alleviate healthcare capacity burdens and associated care costs while improving patient health literacy, quality of life and outcomes.” Lashey added, “The innovation is especially critical given expanding patient populations and soaring infrastructure burdens. The opportunity is to transform clinics with a trusted, scalable platform to support large volume patient populations – by remotely managing individual treatments based on local hospital needs and care team requirements.”

Spain Study Background – Full study abstract (Poster board #C025) is available here.

In the “PRO-WAVE1: Monitoring patient reported outcomes (PROs) in prostate cancer through Wave Health, a novel ePRO health platform” study, patients engaged with the Wave Health App over a 13-week period. Patients used the app during treatment to complete a series of validated ePRO questionnaires, as well as a Weekly Symptom Review (WSR) assessing 16 Prostate cancer-specific symptoms, including the severity and/or frequency of each symptom. A report summary of the patients’ WSR was generated for care team to view in Wave Connect, a web-based platform – specifically for care team members to conduct weekly check-ins on patients, including verifying patient completion, evaluating report content, indicating plans for follow up with each patient, and rating their perceived value of the platform.

Dr. Ignacio Durán, the study primary investigator, based at Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, commented, “This study demonstrates that the platform is very relevant for patients. It is designed to give them an extra layer of care that very likely will translate into better quality of life and potentially longer survival.”

Dr. Estefania Linares, a lead investigator at the Hospital Universitario La Paz, added: “The platform is very practical and would benefit overpopulated hospitals, rural hospitals, and tele-consultations. It is maybe the most useful in departments where you’re not able to see patients frequently because of distance or the overload of patients.”

Hospital participants in the PRO-WAVE1 study included: Hospital Universitario Marques de Valdecilla; Complejo Hospitalario de Navarra; Oncológico de Donostia; Fundació Puigvert Barcelona; Hospital Universitario La Paz; Hospital Universitario Virgen del Rocío; Hospital de la Sta. Creu i Sant Pau; and Hospital Universitarios Cruces.

UK Study Background – Full study abstract (Poster board #MSR208) is available here.

*The Wave Health product has been created by TTI. In the UK, Bayer has partnered with TTI as marketing agent for the prostate cancer version of Wave Health in the UK and is not responsible for the content or function of the product in any way.

The “Enhancing Prostate Cancer Management with Wave Health (Digital Health Platform): A feasibility study” was undertaken by Health Innovation Oxford & Thames Valley and funded by Bayer Plc. The study used the Lean Assessment Process (LAP) methodology to assess the feasibility and barriers associated with adopting Wave Health to harness electronic patient-reported outcomes (ePROs) to support patient self-management and enable care team remote monitoring and risk stratification. Fifteen end-users from 7 NHS trusts, all who routinely make treatment and management decisions within the PC pathway, were interviewed and the study focused on understanding the potential benefits and acceptance for adoption by the NHS, with clinical pathway mapping related to prostate cancer management post-diagnosis.

James Rose, Director of Strategic and Industry Partnerships, Health Innovation Oxford & Thames Valley, said, “Our study indicates Wave Health could add substantial value to the current service and care pathway. We are excited to support the next phase of this work, where we hope to evaluate Wave Health in a real-world setting to further assess its impact on patients, the workforce, service outcomes, and health economics.”

About Health Innovation Oxford and Thames Valley

Health Innovation Oxford and Thames Valley (formerly the Oxford Academic Health Science Network) works with the NHS, research and industry to identify, develop and spread innovation that will benefit patients, populations, services and economies. Email: info@healthinnovationoxford.org / Web: www.healthinnovationoxford.org

About ISPOR Conference

The Professional Society for Health Economics and Outcomes Research global nonprofit is centered on improving healthcare decisions. The ISPOR Europe 2024 conference, themed “Generating Evidence Toward Health and Well-Being,” will be held 17 – 20 November in Barcelona, Spain. The conference program centers on the importance of scientific evidence in understanding and improving the health and well-being of people across the globe. Sessions will focus on the science, practice, and policies of healthcare value assessment and promote a broader view of health economics and outcomes research (HEOR) that considers the physical, mental, and social health aspects of innovation.

About Wave Health

Born from a personal cancer experience, Wave Health is a trusted, comprehensive digital health platform to transform the management and understanding of chronic conditions of large volume patient populations. Comprised of patient app and care portal, the platform efficiently collects, manages, and analyses missing patient reported data from outside the clinical setting (real-time and over the course of treatment). The platform generates actionable insights to drive patient engagement and adherence, and to help medical teams manage individual treatments including identifying emerging risks. For more information, please visit www.wavehealth.app.

1 Immunowave Study (Fred Hutchinson) – two abstract acceptances at ASCO 2023; PRO-WAVE1 Study (Spain) – poster presentation at ASCO GU 2024, abstract acceptance at ASCO 2024, poster presentation at ASCO Breakthrough 2024

Lu, DJ, et al. “Evaluation of Mobile Health Applications to Track Patient-Reported Outcomes for Oncology Patients: A Systematic Review.” Adv Radiat Oncol. Jan-Feb. 2021.

Vercell, Amy, et al. “Patient-Facing Cancer Mobile Apps That Enable Patient Reported Outcome Data to Be Collected” International Journal of Medical Informatics, 25 Nov. 2022.

WAVE HEALTH STUDY EARNS SELECTIVE SPOT FOR POSTER PRESENTATION AT 2024 EUROPEAN UROLOGICAL CANCER CONFERENCE

Lisbon, Portugal and El Segundo, CA – November 11

“PRO-WAVE1: Monitoring patient reported outcomes (PROs) in prostate cancer through Wave Health, a novel ePRO health platform” presents further findings on November 9, 2024.


Lisbon, Portugal and El Segundo, CA – Joining top experts across various cancer fields, including oncology, radiology and urology, Wave Health has been selected for prestigious poster presentation at the 2024 European Multidisciplinary Congress on Urological Cancers (EMUC), focusing on showcasing the latest and most important breakthroughs and best practices in genito-urinary (GU) cancer treatment.

Treatment Technologies & Insights, Inc. (TTI) parent company of the globally recognized Wave Health digital health solution, 1 designed to help both patients and care teams better navigate and manage treatment, presents new findings from an 8-clinic study revealing critical symptom clusters to potentially inform multi-symptom treatment approaches. The novel new analysis of the PRO-WAVE1 real world evidence study data showcases symptom patterns impacting patients’ wellbeing and quality of life, including:

  • Patient-reported symptoms, primarily sad feelings, pain and constipation, are identified as strongest predictors of diminished quality of life.
  • Dynamic Time Warping (DTW) analysis identifies clusters of symptoms with similar severity progression.
  • Visualizing symptom time series within clusters highlights co-occurring patterns with potential to guide targeted, multi-symptom treatment strategies.

“Because of the high patient compliance generated in this study, we had an exciting opportunity to analyze symptom clusters, showcasing the potential of the Wave Health platform to uncover clinically valuable insights into symptom patterns,” said TTI Data and Insights Lead, Hayden Hunskor. “Identifying and understanding these symptom clusters can help patients and healthcare providers better understand factors impacting quality of life and wellbeing. By tracking symptom connectivity over time, we can inform treatment plans and help patients more effectively manage issues simultaneously. This type of analysis opens a world of possibilities for further exploration and learning through longitudinal, holistic data.”

Previous study findings presented at ASCO conferences in the U.S. and Japan, and upcoming up at ISPOR in Barcelona, showed a rare 93% patient compliance, despite a majority of participants being older, less educated, and lacking tech confidence, alongside a 98% HCP perceived usefulness. Additionally, 78% of patients completed a feedback survey, with 90% expressing satisfaction with Wave Health for tracking activities and keeping their medical team informed, and 95% finding the information provided by the app “useful” for their treatment journey, underscoring its positive impact on health management.

Spain Study Background

In the “PRO-WAVE1: Monitoring patient reported outcomes (PROs) in prostate cancer through Wave Health, a novel ePRO health platform” study, patients engaged with the Wave Health App over a 13-week period. Patients used the app during treatment to complete a series of validated ePRO questionnaires, as well as a Weekly Symptom Review (WSR) assessing 16 Prostate cancer-specific symptoms, including the severity and/or frequency of each symptom.  A report summary of the patients’ WSR was generated for care team to view in Wave Connect, a web-based platform – specifically for care team members to conduct weekly check-ins on patients, including verifying patient completion, evaluating report content, indicating plans for follow up with each patient, and rating their perceived value of the platform. 

Dr. Ignacio Durán, primary investigator at Hospital Universitario Marqués de Valdecilla, noted that the platform enhances patient care, likely improving quality of life and survival. Dr. Estefania Linares from Hospital Universitario La Paz emphasized its practicality for overpopulated and rural hospitals, especially where patient visits are infrequent.

About the EMUC Congress

Being the only interdisciplinary event of its kind in Europe, EMUC24 identifies the best therapies, examines current practices, addresses controversies, and reviews emerging technologies. A diverse team of esteemed specialists provide their unique insights and expertise for a multi-faceted take on GU cancers. The EMUC24 congress is a collaboration of the European Society for Medical Oncology (ESMO), the European Society for Radiotherapy and Oncology (ESTRO), and the European Association of Urology (EAU). 

About Wave Health

Born from a personal cancer experience, Wave Health is a trusted digital health platform designed to transform the management and understanding of chronic conditions in large patient populations. It features a care portal and patient app that enhances engagement, compliance and personalized supported self-management while streamlining care workflows through automated communication and novel remote monitoring of patient reported data outside clinical settings. (in real-time and over the course of treatment). The platform generates actionable insights to drive patient engagement and adherence, to help medical teams manage individual treatments and identify emerging risks.

The Wave Health product has been created by TTI. The Spain study was financially supported by Bayer AG. In the UK,

Bayer has partnered with TTI as marketing agent for the prostate cancer version of Wave Health and is not responsible for the content or function of the product in any way.

1 Immunowave Study (Fred Hutchinson) – two abstract acceptances at ASCO 2023; PRO-WAVE1 Study (Spain) – poster presentation at ASCO GU 2024, abstract acceptance at ASCO 2024, poster presentation

at ASCO Breakthrough 2024

Lu, DJ, et al. “Evaluation of Mobile Health Applications to Track Patient-Reported Outcomes for Oncology Patients: A Systematic Review.” Adv Radiat Oncol. Jan-Feb. 2021.

Vercell, Amy, et al. “Patient-Facing Cancer Mobile Apps That Enable Patient Reported Outcome Data to Be Collected” International Journal of Medical Informatics, 25 Nov. 2022.